This episode, like the previous one, consists of a number of short interviews recorded at the Longevity Summit Dublin between 17th and 20th August, featuring a variety of different speakers from the Summit.
In this episode, we'll hear first from Matt Kaeberlein, the CEO of a company called Optispan, following a 20 year period at the University of Washington studying the biological mechanisms of aging and potential interventions to improve healthspan. Among other topics, Matt talks to us about the Dog Aging Project, the Million-Molecule Project, and whether longevity science is at the beginning of the end or the end of the beginning.
Our second speaker is João Pedro de Magalhães who is the Chair of Molecular Biogerontology at the University of Birmingham, where he leads the genomics of aging and rejuvenation lab. João Pedro talks to us about the motivation to study and manipulate the processes of aging, and his work to improve the low-temperature cryopreservation of human organs. You may be surprised at how many deaths are caused by the present lack of such cryopreservation methods.
Third is Steve Horvath, who has just retired from his position as a professor at the University of California, Los Angeles, and is now a Principal Investigator at Altos Labs in Cambridge. Steve is known for developing biomarkers of aging known as epigenetic clocks. He describes three generations of these clocks, implications of mammalian species with surprisingly long lifespans, and possible breakthroughs involving treatments such as senolytics, partial epigenetic reprogramming, and altering metabolic pathways.
The episode rounds off with an interview with Tom Lawry, Managing Director for Second Century Tech, who refers to himself as a recovering Microsoft executive. We discuss his recent bestselling book "Hacking Healthcare", what's actually happening with the application of Artificial Intelligence to healthcare (automation and augmentation), the pace of change regarding generative AI, and whether radiologists ought to fear losing their jobs any time soon to deep learning systems.
Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration